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  • br Conclusions br We have demonstrated the applicability


    5. Conclusions
    We have demonstrated the applicability of the multiplicative (re-lative) risk model to data from glycidol carcinogenicity studies. A good agreement between observed and predicted tumor incidence was shown in glycidol-exposed mice and rats, indicating a relative risk coefficient per internal dose that is approximately independent of tumor site, sex, and species. Further, internal dose measurements of the genotoxic 4u8C improve the accuracy of the risk estimation and enable a more reliable extrapolation between exposure doses and between spe-cies to a risk coefficient for humans.
    We are thankful to Björn Platzack, Marie Eriksson, Camilla Bengtsson, Susanne von Mentzer-Andersson and Jenny Lindahl at Swetox, Södertälje, Sweden for excellent care and treatment of the animals in the metabolism studies. This work was supported the Swedish Research Council Formas (grant number 216-2012-1450) and by Stockholm University, Stockholm, Sweden. The animal metabolism studies were partly financed by the Department of Environmental Medicine (IMM), Karolinska Institute, Solna, Sweden.
    Appendix A. Supplementary data
    Aasa, J., 2018. Cancer Risk Assessment of Glycidol. Evaluation of a Multiplicative Risk Model for Genotoxic Compounds. Doctoral Thesis. Stockholm University,
    Chaundhry, M.Q., Cotterill, J., Watkins, R., Price, N., 2006. The potential of molecular modeling for the prediction of toxicity of compounds generated during heat treat-ment of foods. In: Skog, K., Alexander, J. (Eds.), Acrylamide and Other Health Hazardous Compounds in Heat-Treated Foods. Woodhead Publishing, Cambridge, UK, pp. 132–160.
    Committee on the Biological Effects of Ionizing Radiation (BEIR), 2006. Health Risks from Exposure to Low Levels of Ionizing Radiation: BEIR VII Phase 2. National Research Council, Washington, DC, US National Academies Press.
    Granath, F.N., Vaca, C.E., Ehrenberg, L.G., Törnqvist, M.A., 1999. Cancer risk estimation of genotoxic chemicals based on target dose and a multiplicative model. Risk Anal. 19, 309–320. International Agency for Research on Cancer (IARC), 2000. Glycidol. Some Industrial Chemicals. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, vol. 77. pp. 469–486.
    NTP (National Toxicology Program), 1990. Toxicology and carcinogenesis studies of glycidol (CAS No. 556-52-5) in F344/N rats and B6C3F1 mice (gavage studies). Natl. Toxicol. Progr. Tech. Rep. Ser. 374, 1–229. National Toxicology Program (NTP), 2016. Report on Carcinogens. fourteenth ed. U.S. Department of Health and Human Services, Public Health Service, Research Triangle Park, NC. OECD, Test No 451, 2009. Carcinogenicity Studies, OECD Guidelines for the Testing of Chemicals, Section 4, vol. 491 OECD Publishing, Paris 15 pp.
    Office of Environmental Health Hazard Assessment (OEHHA), 2010. No Significant Risk Level (NSRL) for the Proposition 65 Carcinogen Glycidol. California Environmental Protection Agency, USA 16 pp. Paulsson, B., Granath, F., Grawe, J., Ehrenberg, L., Törnqvist, M., 2001. The multi-plicative model for cancer risk assessment: applicability to acrylamide. Carcinogenesis 22, 817–819.
    Segerbäck, D., 1985. In Vivo Dosimetry of Some Alkylating Agents as a food chain Basis for Risk Estimation. Doctoral Thesis. Stockholm University, Stockholm.
    Törnqvist, M., Paulsson, B., Vikström, A.C., Granath, F., 2008. Approach for cancer risk estimation of acrylamide in food on the basis of animal cancer tests and in vivo dosimetry. J. Agric. Food Chem. 56, 6004–6012. UNSCEAR (United Nations Scientific Committee on the Effects of 4u8C Atomic Radiation), 2000. Sources and Effects of Ionizing Radiation. UNSCEAR 2000 Report to the General Assembly, with Scientific Annexes. United Nations Scientific Committee on the Effects of Atomic Radiation, New York, NY, USA92-1-142238-8.
    U.S. Environmental Protection Agency (U.S. EPA), 2005a. Guidelines for Carcinogen Risk Assessment, EPA/630/P-03/001F. Risk Assessment Forum. U.S. Environmental Protection Agency, Washington, DC, USA 166 pp. U.S. Environmental Protection Agency (U.S. EPA), 2005b. Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens. EPA/630/R-03/ 003F. Risk Assessment Forum. U.S. Environmental Protection Agency, Washington DC, USA 125 pp.
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